Cephalexin: Gram-positive and some Gram-negative organisms including Staphylococcus spp.
Pasteurella spp. Proteus mirabilis. Klebsiella spp., and Escherichia coli. and Pseudomonas spp.
are usually resistant.5
Do not cross the blood-brain barrier (BBB) or enter the eye or the prostate.
Will reach joints, bile and milk.
Will cross the placenta.
Volume of distribution
Metabolism & elimination
following IM injection.
Data not sourced
Not appreciably absorbed orally.25
Bioavailability after S.C. or I.M. injection over 90%.25
following SC injection.
In dogs:121+/- 51 µg/ml.25
In cats:141 +/-12 µg/ml.25
In dogs: 98.5%.25
In cats: 99.8%.25
In dogs: 133+/-16 hours.25
In cats: 166 +/-18 hours.25
Completely absorbed following S.C. injection.25
Data not sourced.
Bioavailability 63% if fasted25
Parameters for oral administration in dogs unless otherwise stated.
Side effects and contra-indications may vary between presentations. Some of those seen more frequently are included here but veterinary surgeons should always refer to the Summary of Product Characteristics (SPC) for full details before prescribing a product.
Side effects include gastrointestinal disturbances such as vomiting and diarrhoea. Use should be avoided in cases of known hypersensitivity to beta-lactam agents.
Disclaimer: Indications and doses may vary between products. The antimicrobials listed may constitute an off licence use of the product and as such should only be used according to the ‘Cascade’, further details of which are available on the RCVS, VMD and NOAH websites. Veterinary surgeons are advised to carefully check the Summary of Product Characteristics (SPC) before prescribing a product and obtain informed owner consent where required.